Regulatory Light Chain Mutants Linked to Heart Disease affect the Cardiac Myosin Lever-Arm
نویسندگان
چکیده
منابع مشابه
Regulatory light chain mutations affect myosin motor function and kinetics.
The actin-based motor protein myosin II plays a critical role in many cellular processes in both muscle and non-muscle cells. Targeted disruption of the Dictyostelium regulatory light chain (RLC) caused defects in cytokinesis and multicellular morphogenesis. In contrast, a myosin heavy chain mutant lacking the RLC binding site, and therefore bound RLC, showed normal cytokinesis and development....
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.883